Dihydroorotate dehydrogenase promotes cell proliferation and suppresses cell death in esophageal squamous cell carcinoma and colorectal carcinoma
نویسندگان
چکیده
Background: Ferroptosis is defined as an iron-dependent non-apoptotic form of programmed cell death. Dihydroorotate dehydrogenase (DHODH) a newly discovered anti-ferroptosis molecule independent from the well-known GPX4 and AIFM2. However, expression pattern especially functional roles DHODH during cancer death are generally unknown.
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ژورنال
عنوان ژورنال: Translational cancer research
سال: 2023
ISSN: ['2218-676X', '2219-6803']
DOI: https://doi.org/10.21037/tcr-23-136